Results: The intraoperative course was successful in all patients, and no perioperative death or complication related to laparoscopic HIPPC was documented. The median follow-up period was 9 months, and the median survival was 7.5 months for all patients. Patients in the Ra/L-OHP group had a median survival of 8.7 months, the Ra/DDP group had a median survival of 5.6 months, and the Ra/MMC group had a median survival of 7.5 months. Patients′ median survival in the Ra/L-OHP group and Ra/MMC group was significantly longer than in the Ra/DDP group (P < .00). No significant difference was found in total remission rate of ascites, increase in the Karnofsky Performance Scale, and incidence rate of port-site metastases among the three groups.
Conclusions: Laparoscopy-assisted HIPPC provides modest yet encouraging efficacy for malignant ascites secondary to disseminated GC.Our preliminary data indicate that the chemotherapeutic combination of Ra/L-OHP and Ra/MMC might be more beneficial compared with Ra/DDP in terms of patients′ survival.